Insight into temperature-dependent microRNA function in mammalian hibernators
نویسندگان
چکیده
Mammalian hibernation involves re-programming of metabolic functions, in part, facilitated by microRNA. Although much is known about microRNA function, we lack knowledge on low temperature microRNA target selection. It is possible that the thermodynamics of microRNA target selection could dictate unique temperature-dependent sets of microRNA targets for hibernators.
منابع مشابه
Molecular Biology of Thermoregulation Invited Review: Molecular adaptations in mammalian hibernators: unique adaptations or generalized responses?
van Breukelen, Frank, and Sandra L. Martin. Invited Review: Molecular adaptations in mammalian hibernators: unique adaptations or generalized responses? J Appl Physiol 92: 2640–2647, 2002; 10.1152/ japplphysiol.01007.2001.—Hibernators are unique among mammals in their ability to attain, withstand, and reverse low body temperatures. Hibernators repeatedly cycle between body temperatures near zer...
متن کاملInvited review: molecular adaptations in mammalian hibernators: unique adaptations or generalized responses?
Hibernators are unique among mammals in their ability to attain, withstand, and reverse low body temperatures. Hibernators repeatedly cycle between body temperatures near zero during torpor and 37 degrees C during euthermy. How do these mammals maintain cardiac function, cell integrity, blood fluidity, and energetic balance during their prolonged periods at low body temperature and avoid damage...
متن کاملMammalian hibernation: differential gene expression and novel application of epigenetic controls.
This review highlights current information about the regulatory mechanisms that govern gene expression during mammalian hibernation, in particular the potential role of epigenetic controls in coordinating the global suppression of transcription. Hibernation is characterized by long periods of deep torpor (when core body temperature drops to near ambient) that are interspersed with brief arousal...
متن کاملEnhancement of RNA Interference Effect in P19 EC Cells by an RNA-dependent RNA Polymerase
Background: RNA interference (RNAi) is a phenomenon uses double-stranded RNA (dsRNA) to specifically inhibit gene expression. The non-specific silencing caused by interferon response to dsRNA in mammalian cells limits the potential of utilizing RNAi to study gene function. Duplexes of 21-nucleotide short interfering dsRNA (siRNA) inhibit gene expression by RNAi. In some organisms, siRNA can als...
متن کاملEndocrine regulation of bone and energy metabolism in hibernating mammals.
Precise coordination among organs is required to maintain homeostasis throughout hibernation. This is particularly true in balancing bone remodeling processes (bone formation and resorption) in hibernators experiencing nutritional deprivation and extreme physical inactivity, two factors normally leading to pronounced bone loss in non-hibernating mammals. In recent years, important relationships...
متن کامل